Process of making phenylglycin.



UNITED STATES- PATENT OFFICE,

FABRIK VON IIEYDEN, ACTIENGESELLSCIIAFT, OF

DRESDEN, SAXONY, GERMANY.

RADEBEUL, NEAR PROCESS OF MAKING RHENYLGLY-CIN.

SPECIFICATION forming part of Letters Patent No. 712,190, dated October as, 1902.

Application filed May 26, 1962, Serial No. 109,075-

10 (L66 wi /fin it may) concern:

Be it known that LWILLIBALD HENTSCHEL, a subject of the Emperor of Russia, and a resident of Radebeul, near Dresden, in the KingdomofSaxony,GermanEmpire,haveinvented a new and useful Improvement in the Manufacture of Pheuylglycin, of which the following is a specification.

This invention relates to a new and improved process for the man ufactureof phenylglycin.

. According to a method described in the Bem'chzfe XXII, page 1799, phenylglycin is produced by heating equal parts, by weight- 1 that is, approximate equimolecular quantities-of anilin and monochloracetic acid with an excess of crystallized acetate of sodium and a small quantity of water. By thisprocess a mixtureis obtained of phenylglycin and 2e phenyliminodiacetic acidcm mucn cooun,

" which must be separated by an ether extraction.

From twenty-five parts of anili'n ten to twelve parts of phenylglycin are obtained.

[No specimens.)

of anilin or more, so that the reaction takes place according ,to theequationclon. .cooi1+sc,n,Nn,=

It is to be recommended that the reaction be allowed to take placein the presence of a diluting agent, among which agents alcohol, water, and mixtures of both, ether, ester, hydrocarbons, and anilin will be preferred.

Example: One hundred parts of monochloracetic acid are boiled for'two hours under reflux with three hundred parts of anilln and two hundred parts of alcohol diluted with Water in a digester provided with a stirrer." Afterward a lye is added till alkaline reaction takes place, and alcohol and anilin are ex- *pelled by the admission of steam. To this solution after it has been perfectly freed of anilin and has cooled down one hundred and twenty parts of a thirty-percent. hydrochloric acid are added, whereby the phenylglycin 6o precipitates as a sandy powder.

What I claim as-my invention is- The herein-described process for the manufacture of phenylglyciu which consists in reacting with one molecule of monochloracetic acid upon three or more molecules'of 'anilin and separating the phenylglycin formed.

In testimonythat I claim the foregoing as my invention I have signed my name, in pres- WILLIBALD IIENTSCHEL. Witnesses: HERNANDO DE So'r0, CARL KNooP.

ence of two witnesses, this 9th day of May, 

